Endocrine Abstracts

Introduction: Cushing’s disease (CD) is a very rare cause of obesity in children. Typical features seen in adults with CD may be absent and clinical investigations may not give a definitive diagnosis. We present a case of CD, highlighting the challenges of diagnosis and the dilemmas encountered in managing such patients.Case report: A ten-year-old girl was referred with a five-year history of weight gain. At presentation BMI was +3.66 SD and she had...

Introduction: Thyroid hormone resistance due to a TRα mutation is rare and only recently described. We report a case of primary hyperparathyroidism in an adult patient with a known TRα mutation.Case presentation: A 60 year old female was referred with hypercalcaemia and hyperparathyroidism that persisted despite correction of vitamin D deficiency. Parathyroid hormone levels continued to be elevated or inappropriately normal with hyper- or normo...

Radioactive isotopes of copper are of interest in the development of imaging agents for positron emission tomography (PET) and companion therapeutics. The synthesis of a ligand, 5-(8-methyl-3,6,10,13,16,19-hexaaza-bicyclo[6.6.6]icosan-1-ylamino)-5-oxopentanoic acid (MeCOSar), designed to form stable complexes with radioactive copper isotopes that can be tethered to tumour targeting peptides and antibodies will be presented.The MeCOSar ligand has been con...

Patient Demographics: 22-month-old female, severe failure to thrive.Past History: Birth weight 5 lb 11 oz at term, grew well for 4 months and then deviating progressively below the curve in height and weight.Physical exam: Length 66 cm (−5.1 SD), weight 6.6 kg (−6.7 SD). Prominent forehead and midfacial hypoplasia noted. Muscle mass decreased.Family history: Mother&#1...

Introduction: ROHHADNET syndrome is a newly described condition characterized by rapid-onset obesity, pulmonary hypoventilation, hythalamic, autonomic dysregulation and, neural tumors. The severity of the clinical manifestations can rapidly lead to death by cardiorespiratory arrest.Case report: We present the case of a 5.10 years old girl, who was admitted in the Endocrinology department for evaluation of a significant weight gain began 2.5 years ago.</p...

Glucagonoma is an exceptional tumor but malignant in 80% of cases. Characteristic signs (migrating necrotic erythema, loss of weight) are connected with glucagon secretion, therefore variable. In this case report, the connection with pre-existent diabetes seems fortuitous.Case report: Mr L, 60 years old, sent in November 2007 for type 2 diabetes 15 years old, unbalanced (HbA1C: 13%), treated by metformin and sulfonylurea, neglected. There is a polyneurop...

Paul Stewart, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK AbstractBorn in Harrogate in 1959, Paul received his undergraduate medical training at Edinburgh University. His house officer and senior house officer posts were undertaken at the Royal Infirmary and Western General Hospital Edinburgh, and it was here that his interest in endocrinology was kindled, largely th...

Paul Stewart, University of Birmingham, UK AbstractBorn in Harrogate in 1959, Paul received his undergraduate Medical training at Edinburgh University. His house officer and senior house officer posts were undertaken at the Royal Infirmary and Western General Hospital Edinburgh, and it was here that his interest in endocrinology was kindled, largely thanks to the clinical skills and mentorship of Christopher Edwards a...

A 29 year old woman with multiple sclerosis and no history of thyroid dysfunction was referred to endocrinology with T3 thyrotoxicosis (TSH <0.01 mU/l, fT4 20.7 pmol/l, T3 2.9 nmol/l). She had received monoclonal alemtuzumab therapy 9 months prior. This hyperthyroid phase was short lived and in the absence of anti-thyroid medication developed symptomatic hypothyroidism within 2 months of referral (TSH 52.9 mU/l, T4 <5 pmol/l, T3 0.8 nmol/l). Thyroid receptor antibodies...

Introduction: Pre-operative localization of parathyroid adenoma is generally done by two localization studies: ultrasonography (US) and parathyroid scintigraphy using 99 m-techentium sestamibi SPECT with CT (Tc-MIBI SPECT/CT), which also report on Incidental thyroid nodules. The aim of our retrospective study was to determine the incidence, characteristics and outcomes of these incidental thyroid findings during parathyroid imaging.Method: A database of ...